Recent Advance in Nucleus-Targeted Fluorescent Probes for Bioimaging, Detection and Therapy

The nucleus is not only the control hub of cell life activities, but also center storing and controlling genetic information. morphology can be used to judge vitality health. various biological molecules contained in are closely related normal occurrence development diseases. In recent years, fluorescence imaging has gained increasing attention due its advantages being intuitive, situ visual. fluorescent probes for high-resolution detection biomolecules great value understanding physiological processes cells or organisms, as well disease diagnosis treatment. this review, we mainly introduce current general strategies designing nucleus-targeted probes, their applications imaging, intranuclear biomolecular therapy. Moreover, discuss challenges opportunities terms selectivity, design so on.